5/7/2023 0 Comments Apple watch pill reminder![]() ![]() Some people have a lot of this enzyme and others just a little. The amount of the CYP3A4 enzyme in the intestine varies from person to person. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. “When there is too much drug in the blood, you may have more side effects.”įor example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure. With most drugs that are affected by grapefruit juice, “the juice lets more of the drug enter the blood,” says Shiew Mei Huang, Ph.D., of the FDA. How Grapefruit Juice Can Interfere With Medications What other fruits or juices may also affect your drug in a similar way to grapefruit juice.How much, if any, grapefruit juice you can have.Talk to your health care provider or pharmacist, and read any information provided with your prescription or non-prescription (OTC) drug to find out: The severity of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink. Grapefruit juice does not affect all the drugs in the categories above. Some antihistamines, such as Allegra (fexofenadine).Some drugs that treat abnormal heart rhythms, such as Pacerone and Cordarone tablet (both amiodarone).Some corticosteroids that treat Crohn’s disease or ulcerative colitis, such as Entocort EC and Uceris tablet (both budesonide). ![]()
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